Selective Serotonin Reuptake Inhibitors (SSRIs) and Markers of Bone Turnover in Men

LJ Williams; M Berk; JM Hodge; MA Kotowicz; AL Stuart; V Chandrasekaran; J Cleminson; JA Pasco

Journal article

Selective Serotonin Reuptake Inhibitors (SSRIs) and Markers of Bone Turnover in Men

LJ Williams, M Berk, JM Hodge, MA Kotowicz, AL Stuart, V Chandrasekaran, J Cleminson, JA Pasco

Calcified Tissue International | SPRINGER | Published : 2018

DOI: 10.1007/s00223-018-0398-0

Abstract

Selective serotonin reuptake inhibitors (SSRIs) have been shown to have a clinically significant impact on bone metabolism. To explore this further, we aimed to determine whether these agents are associated with serum markers of bone turnover utilising a population-based sample of men (n = 1138; 20–96 year) participating in the Geelong Osteoporosis Study. Blood samples were obtained and the bone resorption marker, C-telopeptide (CTx) and formation marker, type 1 procollagen amino-terminal-propeptide (PINP) were measured. Anthropometry and socio-economic status (SES) were determined and information on medication use and lifestyle was obtained via questionnaire. Lifetime mood disorders were as..

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University of Melbourne Researchers

Michael Berk Author

Related Projects (1)

Male osteoporosis: a population based study in geelong

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC), Australia (Projects 299831, 628582, 1009367, 1026265, 1021345, 1104438). LJW is supported by a NHMRC Career Development Fellowship (1064272). MB is supported by a NHMRC Senior Principal Research Fellowship (1059660). VC and JC are supported by Postgraduate Scholarships from Deakin University. The funding providers played no role in the design or conduct of the study; collection, management, analysis and interpretation of the data; or in preparation, review or approval of the manuscript.